Differential signaling by splice variants of the human free fatty acid receptor GPR120.
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Potential roles of GPR120 and its agonists in the management of diabetesOmega-3 Fatty Acids and FFAR4The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsGPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells.Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis.Free fatty acid receptors: structural models and elucidation of ligand binding interactions.Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acidsNovel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle.Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release.Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4.Human Neuropeptide S Receptor Is Activated via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsThe pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismActivation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neuronsLigand-receptor interaction platforms and their applications for drug discovery.Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.The transcriptional programme of the androgen receptor (AR) in prostate cancer.Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail.Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research.FFA4/GPR120 agonists: a survey of the recent patent literature.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer.Fatty acid and mineral receptors as drug targets for gastrointestinal disorders.Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.Polymorphic Variation in FFA Receptors: Functions and Consequences.Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function.ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4.GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue.The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).Free Fatty Acid Receptors and Cancer: From Nutrition to Pharmacology.FFA4/GPR120: Pharmacology and Therapeutic Opportunities.Cloning and characterization of spliced variants of the porcine G protein coupled receptor 120.Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal β-arrestin phosphosensor in Raw 264.7 macrophages.The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
P2860
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P2860
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@en
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@nl
type
label
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@en
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@nl
prefLabel
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@en
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@nl
P2860
P356
P1476
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
@en
P2093
Alastair J H Brown
Sarah-Jane Watson
P2860
P304
P356
10.1124/MOL.111.077388
P577
2012-01-26T00:00:00Z