Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
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Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaRUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationMolecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins.Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion ProteinMouse models of MLL leukemia: recapitulating the human diseaseMolecular studies reveal MLL-MLLT10/AF10 and ARID5B-MLL gene fusions displaced in a case of infantile acute lymphoblastic leukemia with complex karyotype.Array-based comparative genomic hybridization detects copy number variations with prognostic relevance in 80% of ALL with normal karyotype or failed chromosome analysis.t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLLmiR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6.Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.Molecular processes involved in B cell acute lymphoblastic leukaemia.Genomic analysis of a four-way t(4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia.Congenital acute lymphoblastic leukemia case with a novel t(2:4:11) (p21:q21:q23) translocation.
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Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
description
im April 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 05 April 2007
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2007
@uk
name
Complex MLL rearrangements in t
@nl
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
@en
type
label
Complex MLL rearrangements in t
@nl
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
@en
prefLabel
Complex MLL rearrangements in t
@nl
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
@en
P2093
P2860
P50
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P1433
P1476
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele
@en
P2093
L Lo Nigro
M W J C Jansen
T Klingebiel
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P2888
P304
P356
10.1038/SJ.LEU.2404686
P577
2007-04-05T00:00:00Z