A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
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Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptorsSize matters in activation/inhibition of ligand-gated ion channelsPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelCrosslinking constraints and computational models as complementary tools in modeling the extracellular domain of the glycine receptorA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationPreventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.Impact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors.X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitizationStructure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptorMapping convulsants' binding to the GABA-A receptor chloride ionophore: a proposed model for channel binding sites.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domainModular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loopSubunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsRoles for loop 2 residues of alpha1 glycine receptors in agonist activation.Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening.Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop.Using molecular dynamics to elucidate the structural basis for function in pLGICsThe interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.Gating of nicotinic ACh receptors: latest insights into ligand binding and function.Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.The structural mechanism of the Cys-loop receptor desensitization.Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor.Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor.Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels.Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity.Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors.5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet.Dipicrylamine Modulates GABAρ1 Receptors through Interactions with Residues in the TM4 and Cys-Loop Domains.Neurobiology: triggers for channel opening.Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization.
P2860
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P2860
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
@en
type
label
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
@en
prefLabel
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
@en
P2093
P1476
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors
@en
P2093
David C Reeves
Thomas Lemster
P304
P356
10.1523/JNEUROSCI.1045-05.2005
P407
P577
2005-10-01T00:00:00Z