Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop
about
Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptorsThe Intracellular Loop of the Glycine Receptor: It's not all about the SizePathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelInteractions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding ModesCrystal structure of a human GABAA receptorNMR structure of the transmembrane domain of the n-acetylcholine receptor β2 subunitNMR structures of the transmembrane domains of the α4β2 nAChRSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsOpen-channel structures of the human glycine receptor α1 full-length transmembrane domain.X-ray structure of the human α4β2 nicotinic receptorA predicted binding site for cholesterol on the GABAA receptorImpact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors.Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesLength and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitizationIdentifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels.The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channelsChemical and genetic engineering of selective ion channel-ligand interactionsAtomistic insights into human Cys-loop receptors by solution NMR.The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals.Engineering a prokaryotic Cys-loop receptor with a third functional domain.Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function.Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.Crystallization scale purification of α7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system5-HT(3) receptors.Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors.Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsFunctional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop.Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor.Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.Number and locations of agonist binding sites required to activate homomeric Cys-loop receptorsAtomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites.The structural basis of function in Cys-loop receptors.Insights into the structure and pharmacology of GABA(A) receptors.
P2860
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P2860
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@ast
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@en
type
label
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@ast
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@en
prefLabel
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@ast
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@en
P2093
P2860
P356
P1476
Modular design of Cys-loop lig ...... he large cytoplasmic M3M4 loop
@en
P2093
Michaela Jansen
Myles H Akabas
P2860
P304
P356
10.1085/JGP.200709896
P577
2008-02-01T00:00:00Z