WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.
about
Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stressWolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cellsEndoplasmic reticulum stress and the inflammatory basis of metabolic diseaseGenome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biologyWolfram Syndrome: Diagnosis, Management, and TreatmentNew insights from monogenic diabetes for "common" type 2 diabetesRole of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram SyndromeToward beta cell replacement for diabetesWFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cellsWfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathwayExpression and localization of Wolfram syndrome 1 gene in the developing rat pancreasCalcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosisWolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in miceNeuroimaging evidence of deficient axon myelination in Wolfram syndrome.Transcriptional profiling of laser capture microdissected rat arterial elements: fenoldopam-induced vascular toxicity as a model system.Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94The response to unfolded protein is involved in osmotolerance of Pichia pastoris.Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in miceDecreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.A novel CISD2 intragenic deletion, optic neuropathy and platelet aggregation defect in Wolfram syndrome type 2.Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophyA calcium-dependent protease as a potential therapeutic target for Wolfram syndromeA WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.Getting the better of ER stress.A review of the mammalian unfolded protein response.The mitochondrial proteome and human disease.Micro-RNA Binding Site Polymorphisms in the WFS1 Gene Are Risk Factors of Diabetes Mellitus.IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditionsLayer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors.Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1
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P2860
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
WFS1 is a novel component of t ...... ulum in pancreatic beta-cells.
@en
type
label
WFS1 is a novel component of t ...... ulum in pancreatic beta-cells.
@en
prefLabel
WFS1 is a novel component of t ...... ulum in pancreatic beta-cells.
@en
P2093
P2860
P356
P1476
WFS1 is a novel component of t ...... ulum in pancreatic beta-cells.
@en
P2093
Fumihiko Urano
Jenny R Allen
Kathryn L Lipson
Linh X Nguyen
Mariko Fukuma
Sonya G Fonseca
Yoshitomo Oka
P2860
P304
39609-39615
P356
10.1074/JBC.M507426200
P407
P577
2005-09-29T00:00:00Z