Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors.
about
Nicotine binding to brain receptors requires a strong cation-pi interactionNicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug useThe human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and functionPharmacological chaperoning: a primer on mechanism and pharmacologyExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsInside-out neuropharmacology of nicotinic drugsChemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRsMechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein familyEfficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunitsNicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokinesNicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitizationSubtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomicsGABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETA rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences.Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells.Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia.Using pharmacological chaperones to restore proteostasisCharacterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.Activated cholinergic signaling provides a target in squamous cell lung carcinoma.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsCharacterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitizationGABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsNicotine-induced up regulation of α4β2 neuronal nicotinic receptors is mediated by the protein kinase C-dependent phosphorylation of α4 subunits.The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cellsGlutamatergic and GABAergic metabolism in mouse brain under chronic nicotine exposure: implications for addictionNicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoningAcetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.Targeting glutamate homeostasis for potential treatment of nicotine dependence.Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation
P2860
Q24641901-834167D4-44DE-40F2-8ECF-3316463A34CDQ26782271-BF44E225-B2EC-4642-8B5C-54419341E7A5Q26821785-DED128DA-F18A-4B9E-A14E-26879C9566E4Q27001695-75DE8886-7462-41DD-B49E-0BE31F1574FAQ27003966-08FEB2AA-4B4B-40B1-B25B-58F64D39B589Q27010347-121CAA24-16F0-4A35-BEF9-666B54F0754CQ28486758-D3AF6E8F-EC15-4E89-BB7F-331A7D8A6506Q28509139-C76B95B0-D422-4926-AFD3-F20569DE9C88Q28541268-F03A00BF-53F1-4E14-9316-B371FC969B70Q28580107-9DC535DF-D36A-4B4B-A54D-5567C5563640Q30371523-0370B695-831C-4636-80D6-C3E8EA9337ABQ30415560-375BB378-FD9F-4D33-A0C4-CC0A1E2961BBQ30422037-26BD9D78-6F26-4356-8A55-DD0B3C2CC949Q30454356-682DD8EB-A15D-4FBE-A515-17CA8DADA4E0Q30475334-5304D94B-5781-426F-932D-2695F3EF5FD5Q30487079-6A9217F0-9AD9-4E06-9791-04259FD8622DQ30560877-0E22CD9B-CE66-4ED5-9C20-81060A8B00B4Q33310135-47E5CD33-203B-444B-86BC-A168920D9522Q33590316-160FFD98-9B86-4C18-B37C-B42C7AA5E587Q33629366-E48937CD-51C0-4918-BD6B-D31EA3585A27Q33702097-2BFDC11D-4967-49E9-821E-369A56F35153Q33737645-184176C3-7947-4DCF-92BE-AE47078C7959Q33790163-1D2D90CC-B5A2-4E8C-9750-1F19D526FDDDQ33804655-798A3BCD-1E0D-4DBC-A0E7-0A46F1FB9A02Q33815991-068D5F1B-B0D4-4893-BB49-18D06D6E7749Q33833510-5995D4E3-B966-42CD-8F2E-3BC707EA4E0DQ33927508-C0763F11-F3EE-40A9-BDBC-5DD5EAC890FAQ34082354-D910AFAD-FDCA-4661-8769-2E336CB839CAQ34109947-9606637E-0F35-4203-98BF-86C2BC6CDFDCQ34140020-41E0ADE4-323A-4457-8910-CBEF7714A1AAQ34211873-F3F49DF7-C064-40CD-B3F9-518311F47574Q34219565-4CB1DAB9-DA17-4545-966E-03CEA3C5A31BQ34264318-DC7B0D5A-B1A9-42A9-97F2-B0FADBF1C8B5Q34359105-B3CB7CAA-E7C9-4BC5-A3D1-43F845885203Q34439566-6E4B2783-A727-47F6-A2F8-01231B46986CQ34458445-0E49ACA6-EFE4-4335-9EDB-C36F0210C904Q34458500-AC39910A-A892-4F22-8AAB-A97E298FCDF4Q34502468-9B03FA71-E762-4F77-B1FC-DB9F420E7C08Q34517579-6C0257A0-0D82-48BD-9C00-8B71E2D3F156Q34668336-04FDAC26-7AFF-4E3D-93C2-622953DC9D01
P2860
Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Nicotine acts as a pharmacolog ...... beta2 acetylcholine receptors.
@en
type
label
Nicotine acts as a pharmacolog ...... beta2 acetylcholine receptors.
@en
prefLabel
Nicotine acts as a pharmacolog ...... beta2 acetylcholine receptors.
@en
P2093
P356
P1476
Nicotine acts as a pharmacolog ...... beta2 acetylcholine receptors.
@en
P2093
P304
P356
10.1124/MOL.105.012419
P577
2005-09-23T00:00:00Z