Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
about
Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkeyDistal effect of amino acid substitutions in CYP2C9 polymorphic variants causes differences in interatomic interactions against (S)-warfarinCYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drugPrediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.Implications of cytochrome P450 2C9 polymorphism on warfarin metabolism and dosing.Summary of information on human CYP enzymes: human P450 metabolism data.Investigating the Role of Plasma Glucose Concentration as a Phenotypic Marker for CYP2C9 Genetic Variants, in the Diabetic Population of GujaratAssociation of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.Clinical implications of drug interactions with coxibs.Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population.Frequency of cytochrome P450 2C9 mutant alleles in a Korean populationEnantioselective pharmacokinetics of ibuprofen and involved mechanisms.Pharmacogenetics of analgesic drugsThe pharmacogenetics of coumarin therapy.PhRMA white paper on ADME pharmacogenomics.Factors affecting warfarin dose requirements and quality of anticoagulation in adult Egyptian patients: role of gene polymorphism.A PCR method for VKORC1 G-1639A and CYP2C9 A1075C genotyping useful to warfarin therapy among JapaneseSubstrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies -CYP2C9 and warfarin as an example.Homology modeling and substrate binding study of human CYP2C9 enzyme.Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivativesPharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans.CYP2C9*3 Loss-of-Function Allele Is Associated With Acute Upper Gastrointestinal Bleeding Related to the Use of NSAIDs Other Than Aspirin.Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation.CYP2C9*3 influences the metabolism and the drug-interaction of candesartan in vitro.Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.CYP2C9 genetic polymorphisms and warfarin.Effect of factor VII -323 Del/Ins polymorphism on the daily variability of factor VIIc and INR in steady anticoagulated patients with acenocoumarol.Genetic polymorphisms of cytochrome P450 2C9 causing reduced phenprocoumon (S)-7-hydroxylation in vitro and in vivo.Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.Effect of CYP2C9-VKORC1 interaction on warfarin stable dosage and its predictive algorithm.A minimal impact of long-term S-flurbiprofen plaster application on kidney function in osteoarthritis patients.P450 Pharmacogenetics in Indigenous North American Populations.Functional characterization of 32 CYP2C9 allelic variants.Mechanistic insights into the effect of CYP2C9*2 and CYP2C9*3 variants on the 7-hydroxylation of warfarin.An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys.Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects.
P2860
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P2860
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Comparative studies on the cat ...... nac by human liver microsomes.
@en
Comparative studies on the cat ...... nac by human liver microsomes.
@nl
type
label
Comparative studies on the cat ...... nac by human liver microsomes.
@en
Comparative studies on the cat ...... nac by human liver microsomes.
@nl
prefLabel
Comparative studies on the cat ...... nac by human liver microsomes.
@en
Comparative studies on the cat ...... nac by human liver microsomes.
@nl
P2093
P1476
Comparative studies on the cat ...... nac by human liver microsomes.
@en
P2093
Goldstein JA
Guengerich FP
P304
P356
10.1016/S0006-2952(98)00133-6
P407
P577
1998-07-01T00:00:00Z