The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.
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Distinct effects of the mesenchymal dysplasia gene variant of murine Patched-1 protein on canonical and non-canonical Hedgehog signaling pathwaysc-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function.Lactation failure in Src knockout mice is due to impaired secretory activation.EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerizationOncogenes and tumor suppressor genesShc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarityControl of mammary tumor differentiation by SKI-606 (bosutinib).Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisc-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formationLung cancer and lung injury: the dual role of ceramideSrc mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cellsCigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors.Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis.Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosisElevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor ReceptorsMig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasisActivation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseasesCell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt.Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.Calpain4 is required for activation of HER2 in breast cancer cells exposed to trastuzumab and its suppression decreases survival and enhances response.CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone.c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent mannerTyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases.The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants.Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.
P2860
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P2860
The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The c-Src tyrosine kinase asso ...... signaling and transformation.
@en
type
label
The c-Src tyrosine kinase asso ...... signaling and transformation.
@en
prefLabel
The c-Src tyrosine kinase asso ...... signaling and transformation.
@en
P2093
P356
P1433
P1476
The c-Src tyrosine kinase asso ...... d signaling and transformation
@en
P2093
Dongmei Zuo
Harold Kim
Monica Najoukas
Morag Park
Richard Chan
William J Muller
P2888
P304
P356
10.1038/SJ.ONC.1208898
P407
P577
2005-11-01T00:00:00Z
P5875
P6179
1045052962