Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
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Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted MutantsDeconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus.Reengineering the signaling properties of a Src family kinase.c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.Role of Erbin in ErbB2-dependent breast tumor growth.Geldanamycin selectively targets the nascent form of ERBB3 for degradationThe oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisThe epidermal growth factor receptor family: biology driving targeted therapeutics.Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.Binding-induced, turn-on fluorescence of the EGFR/ERBB kinase inhibitor, lapatinibFunctioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activityTrifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signalingTumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cellsProlyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibitionMechanisms of ErbB receptor negative regulation and relevance in cancer.Impact of heat-shock protein 90 on cancer metastasisDrug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.HSP90: chaperone-me-not.The Mysterious Ways of ErbB2/HER2 TraffickingHow Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.SRC family kinases phosphorylate ERBB2Trans-autophosphorylation of p-Y877-ERBB2 heterodimersMolecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.
P2860
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P2860
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@ast
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@en
type
label
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@ast
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@en
prefLabel
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@ast
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@en
P2093
P2860
P356
P1476
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
@en
P2093
Kristin Beebe
Len Neckers
Wanping Xu
Xitong Yuan
Zhexin Xiang
P2860
P304
P356
10.1128/MCB.00899-06
P407
P577
2006-10-09T00:00:00Z