A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysCycling hypoxia and free radicals regulate angiogenesis and radiotherapy responseNovel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential.Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialManganese superoxide dismutase: beyond life and deathDesign of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsRadioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondriaA new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumorsMn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.Enhancement of the radiation response of EMT-6 tumours by a copper octabromotetracarboranylphenylporphyrin.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemHIF-1 and tumour radiosensitivity.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itselfPharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceEarly and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damageLipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Radiation induces aerobic glycolysis through reactive oxygen species.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurationsAntiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorEnhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways.Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cellsMnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cellsMn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cellsRedox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.Anticancer activity of metal complexes: involvement of redox processes.Manganese superoxide dismutase, MnSOD and its mimicsDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.The protective effects of trace elements against side effects induced by ionizing radiation
P2860
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P2860
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
@en
type
label
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
@en
prefLabel
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
@en
P2093
P1476
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
@en
P2093
Benjamin J Moeller
Ines Batinic-Haberle
Ivan Spasojevic
Mark W Dewhirst
Zahid N Rabbani
Zeljko Vujaskovic
P304
P356
10.1016/J.IJROBP.2005.05.026
P407
P577
2005-10-01T00:00:00Z