In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
about
Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsAn orthotopic lung tumor model for image-guided microirradiation in ratsNew molecularly targeted therapies for lung cancerTelomerase: The Devil InsideRoles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapiesTelomerase reverse transcriptase moonlights: Therapeutic targets beyond telomeraseTherapeutic targeting of replicative immortalityTelomerase as a Cancer Target. Development of New MoleculesAntivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRITelomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanismsTelomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanismsTelomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cellsPrinciples of cancer therapy: oncogene and non-oncogene addictionA phase I trial of imetelstat in children with refractory or recurrent solid tumors: a Children's Oncology Group Phase I Consortium Study (ADVL1112).Telomeres and telomerase: from discovery to clinical trials.Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo.Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis.RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Telomeres and aging.Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.Chemotherapeutic approaches for targeting cell death pathways.MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells.Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.A novel bioluminescence orthotopic mouse model for advanced lung cancer.Molecular characterisation of formalin-fixed paraffin-embedded (FFPE) breast tumour specimens using a custom 512-gene breast cancer bead array-based platform.Targeting telomerase-expressing cancer cells.Telomerase and its potential for therapeutic intervention.The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2+ breast cancer cellsTargeting telomerase for cancer therapeuticsImetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeletonTelomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.Therapeutic implications of leukemic stem cell pathwaysNrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.Telomere dysfunction and tumour suppression: the senescence connectionTelomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.Pathogenesis of lung cancer signalling pathways: roadmap for therapies.Pancreatic cancer stem cells: fact or fiction?Effective Targeted Gene Knockdown in Mammalian Cells Using the piggyBac Transposase-based Delivery System.Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer
P2860
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P2860
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
@en
type
label
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
@en
prefLabel
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
@en
P2093
P1433
P1476
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor.
@en
P2093
Ginelle C Gellert
Jerry W Shay
Pakize Dogan
Robert Tressler
Sergei Gryaznov
Shalmica Jackson
Z Gunnur Dikmen
P304
P356
10.1158/0008-5472.CAN-05-1215
P407
P577
2005-09-01T00:00:00Z