FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.
about
Lipid rafts and B cell signalingLinking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosusRethinking mechanisms of autoimmune pathogenesisFcγ Receptors in Solid Organ TransplantationAgammaglobulinemia associated with BCR⁻ B cells and enhanced expression of CD19Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodesFcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.FcγRIIB and autoimmunity.An FcgammaRIIb transmembrane polymorphism in Chinese ITP patients.Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal StudiesFcgamma receptors: structure, function and role as genetic risk factors in SLEThe role of B cells in lupus pathogenesis.T-cell and B-cell signaling biomarkers and treatment targets in lupus.A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosusPathways: Strategies for susceptibility genes in SLE.B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapyCopy number, linkage disequilibrium and disease association in the FCGR locus.Genetic polymorphism of the inhibitory IgG Fc receptor FcgammaRIIb is not associated with clinical outcome in patients with follicular lymphoma treated with rituximab.Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcγRIIB-T/T232) does not impact on kidney transplant or recipient survival.Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.Human FcR polymorphism and disease.Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesisFunctional Fcgamma receptor polymorphisms are associated with human allergy.Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domainFcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivoSystemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.The tipping points in the initiation of B cell signalling: how small changes make big differences.FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK.Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.Quorum sensing contributes to activated IgM-secreting B cell homeostasis.Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.Possible therapeutic applications of single-chain antibodies in systemic autoimmune diseases.FcgammaRIIB as a modulator of autoimmune disease susceptibility.A transmembrane polymorphism in FcgammaRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA.The role of Fc receptors in HIV prevention and therapy.
P2860
Q24680871-11A61C55-B643-48AB-869E-58345ED446B2Q26822662-280B293F-9774-4C97-98B9-4C5D17F44B26Q27024290-FE05FDF5-3BC1-4B93-B4AF-283CC4B8AF79Q28076012-5591B182-49F1-4A4E-9135-161F31C670E7Q30425512-0055D26B-759D-4730-BA9A-1C31C7105593Q30496388-6F6896D2-4790-417E-9AC8-10AAC84630AAQ30612568-445F459A-AB6C-4EC9-891A-784CAB4361D4Q30664429-08D22CDF-EC61-4DD0-BC30-7412E119A7FBQ30981881-5E472CA0-EF36-4D33-8BCF-D82250118A63Q33389828-8E9DC5E5-D3C1-4BE6-B623-B347673DE6E0Q33608479-12CBCFF3-A2B0-4B39-8F32-6C12896F0519Q33686907-AABFD826-B114-45BE-913D-521A65E035CBQ33697484-1B45B1CB-6C2C-48FA-8252-A20E5CA33A2BQ33716669-42EDB215-ED3D-4C84-B646-2FFF322189EBQ33718893-E151DC34-E216-4C85-9777-5B033A26226CQ33842644-B6FACABB-8372-42C2-8C15-F98044A9A4D9Q33843583-0C1D3F7A-F30F-41BB-A932-39C21EC8E6C6Q33923459-969EC0E7-E7D6-49B3-A76B-36BFFC834001Q34013523-4FC57C36-B2ED-453B-AB10-049C4C7F8FB7Q34021588-676D1F8C-B499-41B8-B3DC-0B1F1CE93120Q34106643-82C823D5-7545-4DF6-BE29-347A34DD4A19Q34262292-91A7ECDE-6674-4121-B6E9-86FDDB354DF7Q34319137-3F537173-CB6C-4290-ABB8-64A11A018A68Q34406254-ABEBBF0F-9F47-4138-B421-69BEF5BB4183Q34523062-CADA6D5D-7E57-4A24-BB3F-7E09914678FBQ34752151-BF6B63C9-1F26-4BC1-AAA0-71703A383295Q35106837-F023842B-BF27-4232-8B29-7B7A372E99EEQ35126604-5B0C6189-F00B-482C-8813-05D76F2CD3B8Q35558688-A065CA3D-E0A2-41C1-B952-6D9B3CF55EB3Q35758478-1338D7E8-5680-43BA-8266-8853B601495BQ35986928-956032F0-F541-4726-ADDA-D7F46DB0A7D0Q36121790-75C2F93F-6CB6-4237-A959-FAD60DD57BE5Q36171977-96CABC05-2733-40C6-BC9D-67C95DDCA661Q36409027-8E92C494-B70B-446F-B2C6-390842343694Q36610228-D9CD439C-FFC9-4458-B7BA-3DA767905AD5Q36793513-80822B7F-C860-4257-9244-3BAF57AED998Q36810295-A91D6BC6-2BD2-46B0-9D6C-BE9229EF6875Q36922979-6EBD4C8F-6A84-461C-9A3F-FB0BBC66FB70Q37087771-BFEE24F1-5A57-4AAF-9CFC-093D751113A9Q37113972-86B1BF1C-9326-47BD-9808-5889558B2C29
P2860
FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
FcgammaRIIB Ile232Thr transmem ...... on B cell receptor signaling.
@en
type
label
FcgammaRIIB Ile232Thr transmem ...... on B cell receptor signaling.
@en
prefLabel
FcgammaRIIB Ile232Thr transmem ...... on B cell receptor signaling.
@en
P2093
P2860
P356
P1476
FcgammaRIIB Ile232Thr transmem ...... s on B cell receptor signaling
@en
P2093
Chieko Kyogoku
Hajime Kono
Hiroaki Honda
Katsushi Tokunaga
Kazuhiko Yamamoto
Takeshi Suzuki
Zen-Ichiro Honda
P2860
P304
P356
10.1093/HMG/DDI320
P577
2005-08-22T00:00:00Z