Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
about
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeuticsA chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulationMinimal-length short hairpin RNAs: the relationship of structure and RNAi activityZinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivoAryl hydrocarbon nuclear translocator (hypoxia inducible factor 1beta) activity is required more during early than late tumor growthHypoxia response pathway in border cell migration.A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors.PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery.Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model.Tuning silence: conditional systems for RNA interference.Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitorOverexpression of HIF-1α indicates a poor prognosis in tongue carcinoma and may be associated with tumour metastasis.Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death.Collagen prolyl hydroxylases are essential for breast cancer metastasis.RNA interference and antiviral therapy.Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.Targeting the metabolic microenvironment of tumors.Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.Human cancers converge at the HIF-2alpha oncogenic axis.BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective.Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics.Tetracycline regulated systems in functional oncogenomics.siRNA: novel therapeutics from functional genomics.Inducible RNAi system and its application in novel therapeutics.The Effect of Silencing HIF-1α Gene in BxPC-3 Cell Line on Glycolysis-Related Gene Expression, Cell Growth, Invasion, and Apoptosis.Tumor inhibition by genomically integrated inducible RNAi-cassettes.Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide.Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter.Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.Effects of lentivirus-mediated HIF-1alpha knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells.Defining the optimal parameters for hairpin-based knockdown constructs.Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote MetastasisTargeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome.Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy
P2860
Q29615944-70FC9989-A0D3-4064-9508-2A63A4605D41Q33313078-6614687D-3CE1-4224-8C32-D4BD795D0BC1Q33572896-4DE6DAA4-A899-42BB-A300-0071FE2578D9Q33778211-6BF69C6E-7AA6-4CE0-B912-9B6B0BAF8B03Q34124534-5D88A416-4B15-42C7-B2BF-1D96E3B7893DQ34219465-AA1DB346-330A-414A-864F-C6C0B485F209Q34706669-2B6C97D5-5799-4676-A1C4-8954A6546E4BQ34778484-A44D4881-6EFB-4D56-B783-E2F737F40530Q36076260-64D0AE97-905D-43C5-B56B-CCB8437E0126Q36114046-A1DF9B07-FD79-4080-97EE-87F8DC530BCBQ36575390-5647AE08-0F4D-4609-BED9-BE567C8D815BQ36623493-C0BC9E37-D839-42EE-88D4-983F62460621Q36774441-889BB8BD-369A-4F4D-9D9D-D1C74B4DA31DQ36852171-280E2730-8C1C-4784-A156-D2BD8185C31AQ36891578-25B8FD6D-DC18-44E5-816A-A56CCDE19D8EQ36906597-02F83E39-1B83-4D3D-BA22-0D6F94531949Q36944914-08F2E7B5-1126-4E55-9C51-6B22B1ABD2DEQ37130170-7A82E6BB-1DF3-4D82-8810-8D38B4B7778DQ37157453-DEAA20EF-5279-4F9A-8782-CDA14D48832EQ37229190-A3625D0C-A206-4261-B8B2-A99AB91764A9Q37349436-64B8551B-1B1D-4F87-A266-B57AC1E8815FQ37469123-834F16B3-B22A-466F-856D-15EECB3B7378Q37482150-8E525E3D-73CE-4001-948D-4D4B8A5BFCDAQ37482542-EFA401C0-A59A-4E9B-BA27-73E6F3E10207Q37943792-49C8A90F-9DFE-4A37-ACBD-83A864530BEBQ38084610-C5725421-C5D8-492F-9E2D-8A14759DAEEDQ38104340-BCBF3A22-61C2-4B80-8392-054D0CB30758Q38229425-E989281B-5A88-4C62-8EEF-0970CCA739BFQ38362040-29AC250A-EA00-4A73-9056-841AB277013CQ38818962-8E8595C1-4F74-443A-BF7F-0E0238BA9837Q39114217-5776B0D0-1D1E-494B-9457-A01FAD7D5B45Q39290679-AFA07B20-C87A-497B-9ED9-77F8F85A0D18Q39319634-68E3F6A0-0F99-4227-AC88-94583FD01ED8Q39646942-6CD27650-6A76-4480-A6F4-EC10030B1214Q39762897-E1CD9343-D7A8-4544-A6F5-FE40D4085958Q39990842-306225B0-4B7A-434D-9E3D-3299FE081369Q40094269-FB686746-FD3B-4B90-9B8C-4C2E5DA6C096Q41015404-1AB1577E-DC5C-4760-B987-FD76B17E9843Q41661254-10A2A2DA-B12B-47AD-BFD6-CD95415920B7Q42370561-7A6B4AE0-9A21-49CA-9BFA-CCF8B77C88D7
P2860
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Evaluating hypoxia-inducible f ...... ible RNA interference in vivo.
@en
type
label
Evaluating hypoxia-inducible f ...... ible RNA interference in vivo.
@en
prefLabel
Evaluating hypoxia-inducible f ...... ible RNA interference in vivo.
@en
P2093
P1433
P1476
Evaluating hypoxia-inducible f ...... ible RNA interference in vivo.
@en
P2093
Alexander Shoemaker
Dimitri Semizarov
Leiming Li
Michael Staver
Xiaoyu Lin
P304
P356
10.1158/0008-5472.CAN-04-4426
P407
P577
2005-08-01T00:00:00Z