Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
about
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingPINK1 cleavage at position A103 by the mitochondrial protease PARL.Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionThe kinase domain of mitochondrial PINK1 faces the cytoplasmPINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsBAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradationParkinson's disease proteins: Novel mitochondrial targets for cardioprotectionMitochondrial biology and Parkinson's diseasePrimary skin fibroblasts as a model of Parkinson's diseaseMitochondrial dysfunction and oxidative stress in Parkinson's diseaseEmerging modes of PINK1 signaling: another task for MARK2Protein Kinases and Parkinson's DiseaseMitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expressionGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseOxidative stress and regulation of Pink1 in zebrafish (Danio rerio)PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell deathThe Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypesMitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinA neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.Antioxidants protect PINK1-dependent dopaminergic neurons in DrosophilaThe human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function.Mitochondrial cell death control in familial Parkinson disease.Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63DJ-1, PINK1, and their effects on mitochondrial pathwaysStructural determinants of PINK1 topology and dual subcellular distributionPerturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.Unravelling the role of defective genes.Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase AMitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.The genetics of Parkinson disease.Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.
P2860
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P2860
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Wild-type PINK1 prevents basal ...... son disease-related mutations.
@en
type
label
Wild-type PINK1 prevents basal ...... son disease-related mutations.
@en
prefLabel
Wild-type PINK1 prevents basal ...... son disease-related mutations.
@en
P2093
P50
P356
P1476
Wild-type PINK1 prevents basal ...... son disease-related mutations.
@en
P2093
Agnes Petit
Anurag Tandon
Brian Robinson
Erwan Paitel
Fusheng Chen
Hiroshi Hasegawa
Linda Wang
Michael Scheid
Paul Fraser
Shabnam Salehi-Rad
P304
34025-34032
P356
10.1074/JBC.M505143200
P407
P577
2005-08-02T00:00:00Z