ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.
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Plant Lessons: Exploring ABCB Functionality Through Structural ModelingPfMDR1: mechanisms of transport modulation by functional polymorphismsCatalytic transitions in the human MDR1 P-glycoprotein drug binding sites.Equilibrated atomic models of outward-facing P-glycoprotein and effect of ATP binding on structural dynamics.Molecular models of human P-glycoprotein in two different catalytic statesData-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.Structural characterization of two metastable ATP-bound states of P-glycoprotein.Insight in eukaryotic ABC transporter function by mutation analysis.Binding site of ABC transporter homology models confirmed by ABCB1 crystal structureTransmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.Conformational dynamics of P-glycoprotein in lipid nanodiscs and detergent micelles reveal complex motions on a wide time scale.Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)
P2860
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P2860
ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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name
ATP hydrolysis promotes intera ...... rug resistance P-glycoprotein.
@en
type
label
ATP hydrolysis promotes intera ...... rug resistance P-glycoprotein.
@en
prefLabel
ATP hydrolysis promotes intera ...... rug resistance P-glycoprotein.
@en
P356
P1433
P1476
ATP hydrolysis promotes intera ...... drug resistance P-glycoprotein
@en
P2093
David M Clarke
M Claire Bartlett
P304
10250-10258
P356
10.1021/BI050705J
P407
P50
P577
2005-08-01T00:00:00Z