Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity.
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Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 bindingIdentification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNAEssential amino acids for substrate binding and catalysis of human flap endonuclease 1Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleasesIsolation of a small molecule inhibitor of DNA base excision repair.Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repairEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleGenetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityDynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and productAn open reading frame in intron seven of the sea urchin DNA-methyltransferase gene codes for a functional AP1 endonuclease.Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.Cardiac Cell Senescence and Redox Signaling.Virus world as an evolutionary network of viruses and capsidless selfish elements.Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways.Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.Chinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation.Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C.High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.Functional assessment of population and tumor-associated APE1 protein variantsEnzymology of the repair of free radicals-induced DNA damage.Retrotransposon R1Bm endonuclease cleaves the target sequence.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsCharacterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.Going ape as an approach to cancer therapeutics.Human apurinic/apyrimidinic endonuclease 1.Expression of base excision repair key factors and miR17 in familial and sporadic breast cancerNovel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism.Crystal structure of the endonuclease domain encoded by the telomere-specific long interspersed nuclear element, TRAS1.Conformational dynamics of human AP endonuclease in base excision and nucleotide incision repair pathways.RNA-cleaving properties of human apurinic/apyrimidinic endonuclease 1 (APE1).Apurinic/apyrimidinic (AP) endonuclease from Dictyostelium discoideum: cloning, nucleotide sequence and induction by sublethal levels of DNA damaging agents.Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines.Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease.Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sitesThe exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.Uridylate-specific 3' 5'-exoribonucleases involved in uridylate-deletion RNA editing in trypanosomatid mitochondria.
P2860
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P2860
Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Site-directed mutagenesis of t ...... nuclease and RNase H activity.
@en
type
label
Site-directed mutagenesis of t ...... nuclease and RNase H activity.
@en
prefLabel
Site-directed mutagenesis of t ...... nuclease and RNase H activity.
@en
P2093
P2860
P356
P1476
Site-directed mutagenesis of t ...... nuclease and RNase H activity.
@en
P2093
P2860
P304
P356
10.1093/NAR/23.9.1544
P577
1995-05-01T00:00:00Z