about
A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell lineThe Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complexDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsMyotonia congenita mutation enhances the degradation of human CLC-1 chloride channelsAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.Ubiquitin regulates GGA3-mediated degradation of BACE1Beta-secretase: structure, function, and evolution.Impaired autophagy in sporadic inclusion-body myositis and in endoplasmic reticulum stress-provoked cultured human muscle fibersProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Advances with RNA interference in Alzheimer's disease research.Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in womenA di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinEndolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaquesCathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.Depletion of GGA3 stabilizes BACE and enhances beta-secretase activityNeuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons.Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cellsThe Alzheimer's disease beta-secretase enzyme, BACE1.BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processingDown syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
BACE is degraded via the lysosomal pathway.
@en
type
label
BACE is degraded via the lysosomal pathway.
@en
prefLabel
BACE is degraded via the lysosomal pathway.
@en
P2093
P356
P1476
BACE is degraded via the lysosomal pathway.
@en
P2093
Christine A F von Arnim
Giuseppina Tesco
Young Ho Koh
P304
32499-32504
P356
10.1074/JBC.M506199200
P407
P577
2005-07-20T00:00:00Z