about
Role of dynamin and clathrin in the cellular trafficking of flotillinsGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingThe Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord InjuryTrafficking regulation of proteins in Alzheimer's diseaseGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseAnalysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during developmentMolecular mechanisms of cognitive dysfunction following traumatic brain injuryDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1The normal and pathologic roles of the Alzheimer's β-secretase, BACE1Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's diseaseGenetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinBACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.β-Secretase: its biology as a therapeutic target in diseasesStructure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's diseasePresynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levelsIntracellular trafficking of the β-secretase and processing of amyloid precursor protein.Identification and biology of β-secretase.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondConsequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.Transcriptional and post-transcriptional regulation of β-secretase.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.Endocytic trafficking of membrane-bound cargo: a flotillin point of view.Rheb GTPase regulates β-secretase levels and amyloid β generation
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ubiquitin regulates GGA3-mediated degradation of BACE1
@ast
Ubiquitin regulates GGA3-mediated degradation of BACE1
@en
Ubiquitin regulates GGA3-mediated degradation of BACE1
@nl
type
label
Ubiquitin regulates GGA3-mediated degradation of BACE1
@ast
Ubiquitin regulates GGA3-mediated degradation of BACE1
@en
Ubiquitin regulates GGA3-mediated degradation of BACE1
@nl
prefLabel
Ubiquitin regulates GGA3-mediated degradation of BACE1
@ast
Ubiquitin regulates GGA3-mediated degradation of BACE1
@en
Ubiquitin regulates GGA3-mediated degradation of BACE1
@nl
P2093
P2860
P356
P1476
Ubiquitin regulates GGA3-mediated degradation of BACE1
@en
P2093
Andrew N Cameron
Eugene L Kang
Giuseppina Tesco
Kendall R Walker
P2860
P304
24108-24119
P356
10.1074/JBC.M109.092742
P407
P577
2010-05-18T00:00:00Z