Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions.
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Construction and analysis of a modular model of caspase activation in apoptosisTwo independent positive feedbacks and bistability in the Bcl-2 apoptotic switchCell-to-cell variability in cell death: can systems biology help us make sense of it all?Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIPModeling a snap-action, variable-delay switch controlling extrinsic cell deathBistability in apoptosis by receptor clusteringSTL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classificationDecision-tree based model analysis for efficient identification of parameter relations leading to different signaling statesStochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damageProtective effects of perfluorooctyl-bromide nanoparticles on early brain injuries following subarachnoid hemorrhage in rats.Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways.Understanding dynamics using sensitivity analysis: caveat and solutionA trigger model of apoptosis induced by tumor necrosis factor signaling.Pharmacodynamic modelling of biomarker data in oncology.Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.Modeling heterogeneous responsiveness of intrinsic apoptosis pathwayMeasuring and modeling apoptosis in single cells.The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decisionPDCD5-regulated cell fate decision after ultraviolet-irradiation-induced DNA damage.Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway DynamicsReduction of apoptosis by proanthocyanidin-induced autophagy in the human gastric cancer cell line MGC-803.Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.Identifying fragilities in biochemical networks: robust performance analysis of Fas signaling-induced apoptosis.Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatinEffect of baicalin on hippocampal damage in kainic acid-induced epileptic mice.Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death.The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning.Understanding apoptosis by systems biology approaches.Death ligand concentration and the membrane proximal signaling module regulate the type 1/type 2 choice in apoptotic death signaling.Monte carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in healthy and cancer cells.Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies.Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?Array of translational systems pharmacodynamic models of anti-cancer drugs.Mitochondrial VDAC and hexokinase together modulate plant programmed cell death.Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death.Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death.Dynamics within the CD95 death-inducing signaling complex decide life and death of cells.Signaling perturbations induced by invading H. pylori proteins in the host epithelial cells: a mathematical modeling approach.
P2860
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P2860
Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Effects of Bcl-2 levels on Fas ...... mputational model predictions.
@en
type
label
Effects of Bcl-2 levels on Fas ...... mputational model predictions.
@en
prefLabel
Effects of Bcl-2 levels on Fas ...... mputational model predictions.
@en
P2093
P1476
Effects of Bcl-2 levels on Fas ...... mputational model predictions.
@en
P2093
Cynthia L Stokes
Melanie G Cornejo
Michael H Cardone
P304
P356
10.4049/JIMMUNOL.175.2.985
P407
P577
2005-07-01T00:00:00Z