Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania
about
Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolaeFormation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolaeFormation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania.Drug resistance analysis by next generation sequencing in LeishmaniaPlasticity of the Leishmania genome leading to gene copy number variations and drug resistanceFormation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nucleaseA novel class of developmentally regulated noncoding RNAs in Leishmania.Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania.The expression of biologically active human p53 in Leishmania cells: a novel eukaryotic system to produce recombinant proteinsGene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas.Induction of circles of heterogeneous sizes in carcinogen-treated cells: two-dimensional gel analysis of circular DNA molecules.Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in LeishmaniaParameters controlling the rate of gene targeting frequency in the protozoan parasite Leishmania.Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite LeishmaniaCo-existence of circular and multiple linear amplicons in methotrexate-resistant LeishmaniaThe ribosomal RNA gene promoter and adjacent cis-acting DNA sequences govern plasmid DNA partitioning and stable inheritance in the parasitic protozoan Leishmania.High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells.Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate.Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.Therapeutic immunization with radio-attenuated Leishmania parasites through i.m. route revealed protection against the experimental murine visceral leishmaniasis.
P2860
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P2860
Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Frequent amplification of a sh ...... hotrexate resistant Leishmania
@en
type
label
Frequent amplification of a sh ...... hotrexate resistant Leishmania
@en
prefLabel
Frequent amplification of a sh ...... hotrexate resistant Leishmania
@en
P2093
P2860
P356
P1476
Frequent amplification of a sh ...... hotrexate resistant Leishmania
@en
P2093
Ouellette M
Papadopoulou B
P2860
P304
P356
10.1093/NAR/21.18.4305
P577
1993-09-01T00:00:00Z