Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.
about
The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum.Plasticity of the Leishmania genome leading to gene copy number variations and drug resistanceIsolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance.Secretory pathway of trypanosomatid parasites.Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in micePhenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.Biochemical and molecular mechanisms of drug resistance in parasites.Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts.Global analysis of protein palmitoylation in African trypanosomes.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Deadenylation-independent stage-specific mRNA degradation in LeishmaniaCos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.Genomic Appraisal of the Multifactorial Basis for In Vitro Acquisition of Miltefosine Resistance in Leishmania donovaniThe fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria.Folate metabolic pathways in LeishmaniaDNA transformation of Leishmania infantum axenic amastigotes and their use in drug screeningReduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination.Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major.The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania.Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells.Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate.Distinct 3'-untranslated region elements regulate stage-specific mRNA accumulation and translation in Leishmania.Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania.Reverse Epidemiology: An Experimental Framework to Drive Biomarker Discovery by Functional Genetic Screening Using Relevant Animal Models
P2860
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P2860
Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@en
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@nl
type
label
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@en
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@nl
prefLabel
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@en
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@nl
P2093
P2860
P356
P1433
P1476
Increased transport of pteridi ...... arasite Leishmania tarentolae.
@en
P2093
Papadopoulou B
P2860
P304
P356
10.1093/EMBOJ/18.9.2342
P407
P577
1999-05-01T00:00:00Z