Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line.
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Advances in recombinant antibody manufacturingN-Glycan-based ER Molecular Chaperone and Protein Quality Control System: The Calnexin Binding CycleExperimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell linesAttachment and entry of Chlamydia have distinct requirements for host protein disulfide isomerase.Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress.Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.Comparative metabolic analysis of CHO cell clones obtained through cell engineering, for IgG productivity, growth and cell longevity.Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview.Post-translational modifications in the context of therapeutic proteins.Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein productionLabel-free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines.Engineering mammalian cells in bioprocessing - current achievements and future perspectives.Recombinant antibodies: engineering and production in yeast and bacterial hosts.CHO cells in biotechnology for production of recombinant proteins: current state and further potential.Mammalian cells as biopharmaceutical production hosts in the age of omics.Proteins improving recombinant antibody production in mammalian cells.The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production.Cell line development for biomanufacturing processes: recent advances and an outlook.ATF6β-based fine-tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells.Use of a protein engineering strategy to overcome limitations in the production of "Difficult to Express" recombinant proteins.Development of Genetically Modified Chinese Hamster Ovary Host Cells for the Enhancement of Recombinant Tissue Plasminogen Activator ExpressionMicroarray profiling of preselected CHO host cell subclones identifies gene expression patterns associated with increased production capacity.miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.In search of expression bottlenecks in recombinant CHO cell lines--a case study.Dynamics of unfolded protein response in recombinant CHO cellsA CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression.Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells.Identification of antibody-interacting proteins that contribute to the production of recombinant antibody in mammalian cells.Culture temperature modulates aggregation of recombinant antibody in cho cells.An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting.IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design.Expression of antibodies using single open reading frame (sORF) vector design: Demonstration of manufacturing feasibility.Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cellsEffect of Cysteamine on Cell Growth and IgG4 Production in Recombinant Sp2.0 Cells.Evaluating the bottlenecks of recombinant IgM production in mammalian cells.Preselection of recombinant gene integration sites enabling high transcription rates in CHO cells using alternate start codons and recombinase mediated cassette exchange.Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.IgG Aggregation Mechanism for CHO Cell Lines Expressing Excess Heavy Chains.Development of a novel affinity chromatography resin for platform purification of lambda fabs.
P2860
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P2860
Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Effect of increased expression ...... n a recombinant CHO cell line.
@en
type
label
Effect of increased expression ...... n a recombinant CHO cell line.
@en
prefLabel
Effect of increased expression ...... n a recombinant CHO cell line.
@en
P50
P356
P1476
Effect of increased expression ...... n a recombinant CHO cell line.
@en
P2093
Hermann Katinger
P2860
P304
P356
10.1021/BP0498241
P577
2005-01-01T00:00:00Z