Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins. - Wikidata - awgldk - TriplyDB

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

http://www.wikidata.org/entity/Q40422695

about

Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5 Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins.SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.Engineering botulinum neurotoxin to extend therapeutic intervention.Receptor and substrate interactions of clostridial neurotoxins.Molecular structures and functional relationships in clostridial neurotoxins.Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineering.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.The structure of the tetanus toxin reveals pH-mediated domain dynamics.Unique substrate recognition mechanism of the botulinum neurotoxin D light chain Insights into the different catalytic activities of Clostridium neurotoxins Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis.Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems.Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F.Effects of transgenic expression of botulinum toxins in Drosophila.Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.Specificity of botulinum protease for human VAMP family proteins.Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

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P2860

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

http://www.wikidata.org/entity/Q40422695

description

2008 nî lūn-bûn

@nan

2008年の論文

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2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

@en

type

label

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

@en

prefLabel

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

@en

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Journal of Biological Chemistry

P1476

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

@en

P2093

Stefan Sikorra

http://www.w3.org/2001/XMLSchema#string

Thierry Galli

http://www.w3.org/2001/XMLSchema#string

Thomas Binz

http://www.w3.org/2001/XMLSchema#string

Tina Henke

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P2860

Seven novel mammalian SNARE proteins localize to distinct membrane compartments

A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells

Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity

Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin

Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage

Analysis of the substrate recognition domain determinants of botulinum type B toxin using phage display.

Neurotoxins affecting neuroexocytosis.

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21145-21152

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scholarly article

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10.1074/JBC.M800610200

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30

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283

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2008-05-29T00:00:00Z

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5340324

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18511418

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3258937

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