Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices.
about
Predicting oligonucleotide affinity to nucleic acid targets.Silencing disease genes in the laboratory and the clinicMapping of RNA accessible sites by extension of random oligonucleotide libraries with reverse transcriptase.Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activityPrioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsA rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: correlation with an intracellular pattern and known RNA structuresVariables and strategies in development of therapeutic post-transcriptional gene silencing agentsAntisense therapy for cancer.Inhibition of viral growth by antisense oligonucleotides directed against the IE110 and the UL30 mRNA of herpes simplex virus type-1.Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides.Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond.Recognition and cleavage of hairpin structures in nucleic acids by oligodeoxynucleotides.Effects of RNA secondary structure on cellular antisense activity.Rapid determination of RNA accessible sites by surface plasmon resonance detection of hybridization to DNA arrays.Artificial neural network prediction of antisense oligodeoxynucleotide activityDown-regulation of CD55 and CD46 expression by anti-sense phosphorothioate oligonucleotides (S-ODNs) sensitizes tumour cells to complement attack.Towards genomic drug therapy with antisense oligonucleotides.Angiotensinogen antisense oligonucleotides and fluid intake.
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P2860
Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Predicting antisense oligonucl ...... ams and thermodynamic indices.
@en
type
label
Predicting antisense oligonucl ...... ams and thermodynamic indices.
@en
prefLabel
Predicting antisense oligonucl ...... ams and thermodynamic indices.
@en
P2093
P2860
P356
P1476
Predicting antisense oligonucl ...... ams and thermodynamic indices.
@en
P2093
P2860
P304
P356
10.1093/NAR/20.13.3501
P577
1992-07-01T00:00:00Z