Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation. - Wikidata - awgldk - TriplyDB

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.

http://www.wikidata.org/entity/Q40429251

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Impacts of tissue-type plasminogen activator (tPA) on neuronal survival Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.Adipokines: a link between obesity and dementia?Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor.Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition Tissue-type plasminogen activator-mediated plasminogen activation and contact activation, implications in and beyond haemostasis.Alteplase: a review of its use in the management of acute ischaemic stroke.Beta-amyloidolysis and glutathione in Alzheimer's disease.The effect of chemically modified electrospun silica nanofiber on the mRNA and miRNA expression profile of neural stem cell differentiation.Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor.Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease.The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2.Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells.Activators and inhibitors of the plasminogen system in Alzheimer's disease.NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.Tissue-type plasminogen activator binds to Aβ and AIAPP amyloid fibrils with multiple domains.Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs.The Plasminogen Activator Inhibitor 1 4G/5G Polymorphism and the Risk of Alzheimer's Disease.ERK activation and expression of neuronal cell cycle markers in the hippocampus after entorhinal cortex lesion.Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity.ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors.Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse.Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause.

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Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.

http://www.wikidata.org/entity/Q40429251

description

2005 nî lūn-bûn

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SJ.EMBOJ.7600650

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The EMBO Journal

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Tissue plasminogen activator m ...... oxicity via Erk1/2 activation.

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Carlos G Dotti

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Delia Zafra

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Francesc Alameda

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Jorge E Domínguez

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Manel G Medina

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Maria Dolores Ledesma

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P2860

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

Neuropathological stageing of Alzheimer-related changes

mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

The glamour and gloom of glycogen synthase kinase-3

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

MAP kinase pathways.

The plasminogen (fibrinolytic) system.

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1706-1716

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10.1038/SJ.EMBOJ.7600650

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