ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.
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Organotypic brain slice cultures: A reviewIntraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.Tau Biology and Tau-Directed Therapies for Alzheimer's DiseaseAbeta mediated diminution of MTT reduction--an artefact of single cell culture?Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's diseaseModulation of microglial innate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma.The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review).Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways.Oligomeric amyloid-{beta} inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioningIntranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 miceA rare duplication on chromosome 16p11.2 is identified in patients with psychosis in Alzheimer's diseaseNeuritin can normalize neural deficits of Alzheimer's disease.Amyloid beta-protein assembly and Alzheimer disease.Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects.Modes of Aβ toxicity in Alzheimer's disease.Sinomenine inhibits microglial activation by Aβ and confers neuroprotection.Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics.Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons.Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicityAmyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes.An update on the toxicity of Abeta in Alzheimer's disease.Advances on the understanding of the origins of synaptic pathology in AD.Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approachTau-based treatment strategies in neurodegenerative diseasesAmino acid position-specific contributions to amyloid beta-protein oligomerization.Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer's disease.Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles.Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavageMolecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells.Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway.CSF Biomarkers for Alzheimer's Disease Diagnosis.Tranilast binds to aβ monomers and promotes aβ fibrillation.
P2860
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P2860
ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@en
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@nl
type
label
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@en
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@nl
prefLabel
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@en
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@nl
P2093
P2860
P356
P1476
ERK1/2 activation mediates Abe ...... ic hippocampal slice cultures.
@en
P2093
Andrea J Tenner
Charles G Glabe
Eun Ok Lee
Rakez Kayed
Yoo Jeong Shin
Young Hae Chong
P2860
P304
20315-20325
P356
10.1074/JBC.M601016200
P407
P577
2006-05-18T00:00:00Z