Characterization of the functional insulin binding epitopes of the full-length insulin receptor.
about
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsThe A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceDesign of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONSProtective hinge in insulin opens to enable its receptor engagementEngineering of insulin receptor isoform-selective insulin analoguesAromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic designHigh-affinity insulin binding: insulin interacts with two receptor ligand binding sites.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormoneFlexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.How IGF-1 activates its receptor.The insulin receptor: a new target for cancer therapy.Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir.α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.Theoretical and computational studies of peptides and receptors of the insulin family.Insulin mimetic peptide S371 folds into a helical structure.Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer.A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni.Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.
P2860
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P2860
Characterization of the functional insulin binding epitopes of the full-length insulin receptor.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
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2005年學術文章
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2005年學術文章
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name
Characterization of the functi ...... full-length insulin receptor.
@en
type
label
Characterization of the functi ...... full-length insulin receptor.
@en
prefLabel
Characterization of the functi ...... full-length insulin receptor.
@en
P2860
P356
P1476
Characterization of the functi ...... full-length insulin receptor.
@en
P2093
Jonathan Whittaker
Linda Whittaker
P2860
P304
20932-20936
P356
10.1074/JBC.M411320200
P407
P577
2005-03-30T00:00:00Z