Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis.
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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activationThe A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceProtective hinge in insulin opens to enable its receptor engagementCrystal structure of the first three domains of the type-1 insulin-like growth factor receptorIdentification of a heregulin binding site in HER3 extracellular domainThe three dimensional structure of the type I insulin-like growth factor receptor.Characterization of an insulin from the three-toed amphiuma (Amphibia: Urodela) with an N-terminally extended A-chain and high receptor-binding affinityIn silico saturation mutagenesis and docking screening for the analysis of protein-ligand interaction: the Endothelial Protein C Receptor case study.A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.Functionally significant insulin-like growth factor I receptor mutations in centenariansFlexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.Three-dimensional structural interactions of insulin and its receptor.How IGF-1 activates its receptor.Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.Theoretical and computational studies of peptides and receptors of the insulin family.Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.Characterization of the functional insulin binding epitopes of the full-length insulin receptor.Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain.Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding.Structural determinants of the insulin receptor-related receptor activation by alkali.A docking study of insulin with LI-CR-L2 ecto domain of insulin receptor: an easy way for preliminary screening of novel anti-diabetic peptidesCrystallization of the first three domains of the human insulin-like growth factor-1 receptor.Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors.Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site.Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors
P2860
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P2860
Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Mapping of an NH2-terminal lig ...... alanine scanning mutagenesis.
@en
type
label
Mapping of an NH2-terminal lig ...... alanine scanning mutagenesis.
@en
prefLabel
Mapping of an NH2-terminal lig ...... alanine scanning mutagenesis.
@en
P2093
P2860
P356
P1476
Mapping of an NH2-terminal lig ...... alanine scanning mutagenesis.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.7.3012
P407
P577
1995-02-01T00:00:00Z