Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
about
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structureA vertebrate gene, ticrr, is an essential checkpoint and replication regulatorMultifunctional transcription factor TFII-I is an activator of BRCA1 functionIdentification of DBC1 as a transcriptional repressor for BRCA1PML colocalizes with and stabilizes the DNA damage response protein TopBP1Coordination of DNA damage responses via the Smc5/Smc6 complexPTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiaeA DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeastBRCT domain-containing protein PTIP is essential for progression through mitosisRegulatory motifs in Chk1Activation of the DNA damage checkpoint in mutants defective in DNA replication initiationGerminating fission yeast spores delay in G1 in response to UV irradiationPR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNABRCT domain-containing protein TopBP1 functions in DNA replication and damage responseCooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage responseChecking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorViral infections and cell cycle G2/M regulationA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointThe Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatinPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointTopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpointRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombep53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksSite-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.Viral transport of DNA damage that mimics a stalled replication fork.The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilizationImportance of a C-terminal conserved region of Chk1 for checkpoint function.Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases.Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.Rad18 is required for DNA repair and checkpoint responses in fission yeast.The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.
P2860
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P2860
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Damage and replication checkpo ...... RCT motif, with Cut5 and Chk1.
@en
type
label
Damage and replication checkpo ...... RCT motif, with Cut5 and Chk1.
@en
prefLabel
Damage and replication checkpo ...... RCT motif, with Cut5 and Chk1.
@en
P2093
P2860
P356
P1433
P1476
Damage and replication checkpo ...... RCT motif, with Cut5 and Chk1.
@en
P2093
P2860
P304
P356
10.1101/GAD.11.24.3387
P577
1997-12-01T00:00:00Z