Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.
about
5-HT3 receptorsThe 5-HT3 receptor as a therapeutic targetPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelInvestigation of the structure of anti-human seminal plasma protein single-chain antibody and its association with linker peptide lengthThe binding orientations of structurally-related ligands can differ; A cautionary noteAgonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using a molecular rulerThe binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptorsA cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.Structural answers and persistent questions about how nicotinic receptors work.Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors.Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptors.Loop B is a major structural component of the 5-HT3 receptor.The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors.A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.Calcium modulation of 5-HT3 receptor binding and function.Colchicine: a novel positive allosteric modulator of the human 5-hydroxytryptamine3A receptorThe auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?The structural basis of function in Cys-loop receptors.Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives.Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket.Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands.Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBPDesign, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands.Optimization modeling of single-chain antibody against hepatoma based on similarity algorithmDefining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptorUnbinding pathways of an agonist and an antagonist from the 5-HT3 receptorOndansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesisThe extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study.A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors.
P2860
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P2860
Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Locating an antagonist in the ...... eling and radioligand binding.
@en
type
label
Locating an antagonist in the ...... eling and radioligand binding.
@en
prefLabel
Locating an antagonist in the ...... eling and radioligand binding.
@en
P2093
P2860
P356
P1476
Locating an antagonist in the ...... deling and radioligand binding
@en
P2093
Andrew J Thompson
David C Reeves
S Ling Chan
Sarah C R Lummis
P2860
P304
20476-20482
P356
10.1074/JBC.M413610200
P407
P577
2005-03-21T00:00:00Z