Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
about
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingGenotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancerRole of DNA-dependent protein kinase catalytic subunit in cancer development and treatmentIncreased genomic alteration complexity and telomere shortening in B-CLL cells resistant to radiation-induced apoptosis.Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks.Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in malesTaking a Bad Turn: Compromised DNA Damage Response in LeukemiaCharacterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response.Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization.NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor.CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive DivisionFludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removalA new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AXNew molecular markers in resistant B-CLL.Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells.Purification and identification of positive regulators binding to a novel element in the c-Jun promoter.Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib.DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7.ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia.Increased cellular accumulation and distribution of amrubicin contribute to its activity in anthracycline-resistant cancer cells.A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in Daudi cells.Impaired NHEJ function in multiple myelomaDNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells.Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia.Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells.Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro.Personalizing treatment for chronic lymphocytic leukemia.miR4673 improves fitness profile of neoplastic cells by induction of autophagy
P2860
Q26863501-40F6EB44-68DD-49FF-93B2-8E2FB1E46855Q27007505-D81EC32F-D96B-4F30-BADC-BF9C728E1E19Q28274124-A850A2B3-0CB1-4705-BEBC-B6F97084D6E7Q33620305-1738004E-3927-44A5-B937-B2EBBEBEDCC2Q33638819-DCB07492-8F8A-468F-A1AB-76CDCC821D9DQ33742884-4F77A2ED-3C45-47AC-BE68-0AA564D33AEAQ33855938-123428AC-6568-406F-974B-3BDC0D8EC8C2Q34240365-0706F24D-1E70-4793-AC0A-8B1F56B74DEFQ34887304-6E4E3CE3-B19C-4942-88D8-2F0F3C410F00Q35551885-CD753C1F-DFF1-43D8-B12F-44F00B727183Q35815012-9C05989E-418D-42A0-9228-DE867043B4C9Q35848805-2CAE1D94-0EA9-48B7-B797-65C6B0BE513EQ36413959-14602428-DD0C-49DF-8BB7-7D608085301AQ36415162-470F9D61-B264-4ED9-A182-FFD8B9509FE4Q36497411-2FCE3366-2EC5-4E91-A8AA-92CEE05E36DBQ36914584-09C7B999-8140-4190-9B86-70509D7DA41DQ37229934-F3BF049B-B4A8-4830-8832-557DEAD0E252Q38288403-BB382D0E-D35E-40D0-9978-90F68AE2FBA3Q38742492-3E7B06BA-37C2-420E-9807-55B1C7E8D40FQ38756630-6A3D7F1B-90BC-4196-9C4E-A762267B9E3AQ38891225-92354D61-5C9F-45FF-8036-715D92FE6A49Q39436550-06786BC2-32F5-4A6F-8051-1CC82F46CDD9Q39737535-5730DB88-1396-4656-AB72-8D2AB17D5C1DQ39913010-8FBD46A7-4C47-455E-B4D6-B83DF3D2DC99Q39977573-AE245F68-541B-4767-94F6-512146B78B62Q40282659-2F1FF892-D50E-43AD-9743-0184F5C38531Q41233958-6F54307F-F27E-4BEB-B41B-A42FC0919CFAQ42191925-5D144288-3061-47B0-90C7-586DC4D638E5Q42316990-038832CF-2975-4892-95DC-8FB343CC6157Q42837099-7BCCD04D-EB21-4991-8075-3269D0AE6FF7Q54612791-2D07BC32-B2BA-4FD4-8952-5FE686B9D9CEQ57809713-6DBED4AA-552D-4084-8C22-283D9C78C82F
P2860
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Human chronic lymphocytic leuk ...... nd-joining DNA repair pathway.
@en
type
label
Human chronic lymphocytic leuk ...... nd-joining DNA repair pathway.
@en
prefLabel
Human chronic lymphocytic leuk ...... nd-joining DNA repair pathway.
@en
P2093
P50
P921
P1433
P1476
Human chronic lymphocytic leuk ...... nd-joining DNA repair pathway.
@en
P2093
Bernard Salles
Catherine Muller
Gaby Potocki-Veronese
Jacques-Louis Binet
Jozo Delic
Michelle Ricoul
Olivier Guipaud
Vincent Favaudon
Zofia Maciorowski
P304
P356
10.1182/BLOOD-2004-07-2888
P407
P577
2005-02-17T00:00:00Z