Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?
about
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyBlood cells: an historical account of the roles of purinergic signallingP2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cellsA molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation.Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.Deciphering the human platelet sheddome.Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cellsCharacterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500)The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.Extracellular nucleotides as negative modulators of immunity.Hemostatic function of apheresis platelets stored at 4°C and 22°C.Platelet signaling-a primer.Molecular mechanisms of platelet P2Y(12) receptor regulation.P2 receptors and platelet function.Historical perspective on ADP-induced platelet activation.Disabled-2: A modular scaffold protein with multifaceted functions in signaling.The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding.Calmodulin interacts with the platelet ADP receptor P2Y1Desensitization of endothelial P2Y1 receptors by PKC-dependent mechanisms in pressurized rat small mesenteric arteries.Reciprocal regulation of platelet responses to P2Y and thromboxane receptor activation.Platelet ADP response deteriorates in synthetic storage media.Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor.Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading.
P2860
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P2860
Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Differential regulation and re ...... loss of hemostatic properties?
@en
type
label
Differential regulation and re ...... loss of hemostatic properties?
@en
prefLabel
Differential regulation and re ...... loss of hemostatic properties?
@en
P2093
P50
P356
P1476
Differential regulation and re ...... loss of hemostatic properties?
@en
P2093
Anthony Baurand
Béatrice Hechler
Christian Gachet
Jean-Luc Galzi
Jean-Pierre Cazenave
P304
P356
10.1124/MOL.104.004846
P577
2004-12-15T00:00:00Z