Celastrols as inducers of the heat shock response and cytoprotection.
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Caloric restriction and exercise "mimetics'': Ready for prime time?Protein homeostasis as a therapeutic target for diseases of protein conformationChemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisKeep your heart in shape: molecular chaperone networks for treating heart diseaseThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologySmall Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone MachineryHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesHsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysisActivation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effectsCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersQuantitative proteomics reveals cellular targets of celastrolCelastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stressLarge-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and agingCelastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death.Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injuryPreclinical studies of celastrol and acetyl isogambogic acid in melanoma.Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.High-content image-based screening for small-molecule chaperone amplifiers in heat shock.Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative diseaseEnhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathwayCelastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase.Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease.Getting folded: chaperone proteins in muscle development, maintenance and disease.Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.Hsp70 and its molecular role in nervous system diseasesHeat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B', in differentiated human neuronal cells.Immunomodulation of Autoimmune Arthritis by Herbal CAMCelastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.Regulation of the mammalian heat shock factor 1.The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response.Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomasAnticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.
P2860
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P2860
Celastrols as inducers of the heat shock response and cytoprotection.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Celastrols as inducers of the heat shock response and cytoprotection.
@en
type
label
Celastrols as inducers of the heat shock response and cytoprotection.
@en
prefLabel
Celastrols as inducers of the heat shock response and cytoprotection.
@en
P2093
P356
P1476
Celastrols as inducers of the heat shock response and cytoprotection
@en
P2093
Bessie N A Mbadugha
John P Devlin
Joshua D Bosman
Richard B Silverman
Richard I Morimoto
Sandy D Westerheide
Soojin Kim
Tiara L A Kawahara
P304
56053-56060
P356
10.1074/JBC.M409267200
P407
P577
2004-10-26T00:00:00Z