Synthetic partial agonists reveal key steps in IP3 receptor activation.
about
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptorStructural and functional conservation of key domains in InsP3 and ryanodine receptorsA bead aggregation assay for detection of low-affinity protein-protein interactions reveals interactions between N-terminal domains of inositol 1,4,5-trisphosphate receptorsBinding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptorsStimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3Analysis of protein-ligand interactions by fluorescence polarizationTriazolophostins: a library of novel and potent agonists of IP3 receptors.Designer small molecules to target calcium signalling.Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.Identification of functionally critical residues in the channel domain of inositol trisphosphate receptorsGerm stem cells are active in postnatal mouse ovary under physiological conditions.Characterization of a flatworm inositol (1,4,5) trisphosphate receptor (IP₃R) reveals a role in reproductive physiologyCaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.IP(3) receptors: toward understanding their activation.Themes and variations in ER/SR calcium release channels: structure and function.Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.Structural organization of signalling to and from IP3 receptors.Patch-clamp electrophysiology of intracellular Ca2+ channels.Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.IP3 receptor mutations and brain diseases in human and rodents.Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domainActivation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+ release through IP3 receptorsDecrease in expression of maternal effect gene Mater is associated with maternal ageing in mice.Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signalling Junctions and Protein Kinase A.Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.Cyclic AMP directs inositol (1,4,5)-trisphosphate-evoked Ca2+ signalling to different intracellular Ca2+ storesThree-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor.A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns.Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors.
P2860
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P2860
Synthetic partial agonists reveal key steps in IP3 receptor activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Synthetic partial agonists reveal key steps in IP3 receptor activation.
@en
type
label
Synthetic partial agonists reveal key steps in IP3 receptor activation.
@en
prefLabel
Synthetic partial agonists reveal key steps in IP3 receptor activation.
@en
P2093
P2860
P356
P1476
Synthetic partial agonists reveal key steps in IP3 receptor activation.
@en
P2093
Ana M Rossi
Andrew M Riley
Barry V L Potter
Colin W Taylor
Emily J A Taylor
Olivier Dellis
Stephen C Tovey
Taufiq Rahman
Valery G Veresov
P2860
P2888
P304
P356
10.1038/NCHEMBIO.195
P577
2009-08-09T00:00:00Z