Transcriptional activation of c-myc proto-oncogene by WT1 protein.
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The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cellsDLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYCDynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiationThe Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/OmiThe Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells.Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemiasGlucose signaling in Saccharomyces cerevisiae.Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia.Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms.Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repressionThe Wilms' tumour suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes.Diagnostic value of Wilms tumor 1 and CD44 in Langerhans cell sarcoma: case series of 4 patients.The Wilms' tumor suppressor WT1 regulates expression of members of the epidermal growth factor receptor (EGFR) and estrogen receptor in acquired tamoxifen resistance.The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL (tumor necrosis factor α-related apoptosis-inducing ligand) by regulating the antiapoptotic protein Bcl-xLA GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiationTranscriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma.Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways.Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation.Opposite regulation of estrogen receptor-α and its variant ER-α36 by the Wilms' tumor suppressor WT1.HtrA2, taming the oncogenic activities of WT1.Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements.DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and -KTS isoforms-From initial observations to recent global genomic analyses.The CUG-translated WT1, not AUG-WT1, is an oncogene.Role of ZNF224 in c-Myc repression and imatinib responsiveness in chronic myeloid leukemia.WT1 protein is cleaved by caspase-3 in apoptotic leukemic cells.Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities.ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.
P2860
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P2860
Transcriptional activation of c-myc proto-oncogene by WT1 protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Transcriptional activation of c-myc proto-oncogene by WT1 protein.
@en
type
label
Transcriptional activation of c-myc proto-oncogene by WT1 protein.
@en
prefLabel
Transcriptional activation of c-myc proto-oncogene by WT1 protein.
@en
P2093
P2860
P356
P1433
P1476
Transcriptional activation of c-myc proto-oncogene by WT1 protein.
@en
P2093
Mark D Minden
Serban San-Marina
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207609
P407
P577
2004-09-01T00:00:00Z
P5875
P6179
1021562680