Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.
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GPCR oligomers in pharmacology and signalingA heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCRDistinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein couplingCell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerizationCalcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomersStructures of the extracellular regions of the group II/III metabotropic glutamate receptorsNeurobiological Insights from mGlu Receptor Allosteric Modulation.Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2Structural mechanism of ligand activation in human GABAB receptormu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesisG protein-coupled receptor heterocomplexes in neuropsychiatric disorders.Metabotropic glutamate receptors: from the workbench to the bedside.On the fitting of binding data when receptor dimerization is suspected.Fluorophore-assisted light inactivation produces both targeted and collateral effects on N-type calcium channel modulation in rat sympathetic neurons.Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.Structure and ligand recognition of class C GPCRsDysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismNanobodies to Study G Protein-Coupled Receptor Structure and Function.Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoniCrosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues.Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alphaAllosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophreniaHead-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats.Interdomain movements in metabotropic glutamate receptor activation.Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.Oligomerization of G protein-coupled receptors: past, present, and future.Conformational dynamics of a class C G-protein-coupled receptorFunctional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers.Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors.Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptorsCross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.G protein-coupled receptor oligomerization provides the framework for signal discrimination.How and why do GPCRs dimerize?
P2860
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P2860
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Closed state of both binding d ...... is required for full activity.
@en
type
label
Closed state of both binding d ...... is required for full activity.
@en
prefLabel
Closed state of both binding d ...... is required for full activity.
@en
P2093
P50
P356
P1476
Closed state of both binding d ...... is required for full activity
@en
P2093
Anne-Sophie Bessis
Hervé Ansanay
Laurent Prézeau
P2888
P304
P356
10.1038/NSMB794
P577
2004-07-04T00:00:00Z