Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. - Wikidata - awgldk - TriplyDB

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

http://www.wikidata.org/entity/Q40550747

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Molecular targets for flavivirus drug discovery A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties Nucleoside inhibitors of tick-borne encephalitis virus Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance Role of Marine Natural Products in the Genesis of Antiviral Agents Finally sofosbuvir: an oral anti-HCV drug with wide performance capability Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Triaryl pyrazoline compound inhibits flavivirus RNA replication.Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues Viral Determinants of Resistance to Treatment in Patients with Hepatitis C Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase Synergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral Targets Evolution of Resistant M414T Mutants among Hepatitis C Virus Replicon Cells Treated with Polymerase Inhibitor A-782759 Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors Phenotypic Characterization of Resistant Val36 Variants of Hepatitis C Virus NS3-4A Serine Protease The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication Synergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase Inhibitors The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase The FDA-approved drug sofosbuvir inhibits Zika virus infection Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.

P2860

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P2860

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

http://www.wikidata.org/entity/Q40550747

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Characterization of resistance ...... C virus replication in vitro.

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Characterization of resistance ...... C virus replication in vitro.

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Characterization of resistance ...... C virus replication in vitro.

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P1433

Journal of Biological Chemistry

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Characterization of resistance ...... C virus replication in vitro.

@en

P2093

Alessandra Ceccacci

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Anne B Eldrup

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Balkrishen Bhat

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Daria J Hazuda

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David B Olsen

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Giovanni Migliaccio

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Joanne E Tomassini

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Krista L Getty

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Lawrence F Colwell

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Licia Tomei

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P2860

Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

Persistent Replication of Hepatitis C Virus Replicons Expressing the -Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

A mechanism for initiating RNA-dependent RNA polymerization

Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

Efficient initiation of HCV RNA replication in cell culture

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

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49164-49170

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scholarly article

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10.1074/JBC.M305041200

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P433

49

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P478

278

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Daniel R McMasters

Raffaele De Francesco

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2003-09-08T00:00:00Z

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5268951

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12966103

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