Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.
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Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingKaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentPharmacologic resistance in colorectal cancer: a reviewRegulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulationTranscription factor TAFII250 promotes Mdm2-dependent turnover of p53Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairmentPhosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodelingMEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signalingRelA/p65 regulation of IkappaBbeta.Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyTyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria.A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.The ubiquitination code: a signalling problem.Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis.Physiological regulation of Akt activity and stability.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysMdm2 links genotoxic stress and metabolism to p53.Tomato SlSnRK1 protein interacts with and phosphorylates βC1, a pathogenesis protein encoded by a geminivirus β-satellite.Detection of functional single-nucleotide polymorphisms that affect apoptosisDosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.MDM2, MDMX and p53 in oncogenesis and cancer therapyEnigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.Essential role for focal adhesion kinase in regulating stress hematopoiesis.Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2.MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway.Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeInhibitors of Glioma Growth that Reveal the Tumour to the Immune System.Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responsesMir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interactionInvolvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells
P2860
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P2860
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Stabilization of Mdm2 via decr ...... Akt-dependent phosphorylation.
@en
type
label
Stabilization of Mdm2 via decr ...... Akt-dependent phosphorylation.
@en
prefLabel
Stabilization of Mdm2 via decr ...... Akt-dependent phosphorylation.
@en
P2093
P356
P1476
Stabilization of Mdm2 via decr ...... Akt-dependent phosphorylation.
@en
P2093
Adrian Merlo
Brian A Hemmings
Daniel Hess
Derek P Brazil
Jianhua Feng
Rastislav Tamaskovic
Zhongzhou Yang
P304
35510-35517
P356
10.1074/JBC.M404936200
P407
P577
2004-05-28T00:00:00Z