A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
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Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesLRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergyOncosuppressive functions of decorinExpanding the ubiquitin code through post-translational modificationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesStructural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligaseAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainEzrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityThe N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa.High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cellsMet/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.Exploitation of the ubiquitin system by invading bacteriaRON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasiac-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).From Tpr-Met to Met, tumorigenesis and tubes.Signal transduction of fertilization in frog eggs and anti-apoptotic mechanism in human cancer cells: common and specific functions of membrane microdomains.Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis.MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapy.Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.Regulation of the MET oncogene: molecular mechanisms.EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.Met receptor tyrosine kinase degradation is altered in response to the leucine-rich repeat of the Listeria invasion protein internalin B.Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor.Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity.Epidermal growth factor and/or growth hormone induce differential, side-specific signal transduction protein phosphorylation in enterocytes.The Antitumor Effect of C-terminus of Hsp70-Interacting Protein via Degradation of c-Met in Small Cell Lung Cancer.Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.
P2860
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P2860
A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
A conserved DpYR motif in the ...... ssion of oncogenic activation.
@en
type
label
A conserved DpYR motif in the ...... ssion of oncogenic activation.
@en
prefLabel
A conserved DpYR motif in the ...... ssion of oncogenic activation.
@en
P2093
P2860
P356
P1476
A conserved DpYR motif in the ...... ession of oncogenic activation
@en
P2093
Morag Park
Noboru Ishiyama
Stan Lipkowitz
P2860
P304
29565-29571
P356
10.1074/JBC.M403954200
P407
P577
2004-04-29T00:00:00Z