Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. - Wikidata - awgldk - TriplyDB

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.

http://www.wikidata.org/entity/Q34097397

about

VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase The MET axis as a therapeutic target.c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130 LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases MET: a critical player in tumorigenesis and therapeutic target Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3 The clinical and functional significance of c-Met in breast cancer: a review Biology of MET: a double life between normal tissue repair and tumor progression Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism Cbl controls EGFR fate by regulating early endosome fusion.Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation.In-cell biochemistry using NMR spectroscopy.Effects of miR-193a and sorafenib on hepatocellular carcinoma cells.Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized Roles of E3 ubiquitin ligases in cell adhesion and migration.Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia.Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4 Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail.Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.The role of the c-Met pathway in lung cancer and the potential for targeted therapy.In-depth proteomic analysis of six types of exudative pleural effusions for nonsmall cell lung cancer biomarker discovery.Functional consequence of the MET-T1010I polymorphism in breast cancer MET exon 14 deletion (METex14): finally, a frequent-enough actionable oncogenic driver mutation in non-small cell lung cancer to lead MET inhibitors out of "40 years of wilderness" and into a clear path of regulatory approval Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells From Tpr-Met to Met, tumorigenesis and tubes.Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions.MET as a target for treatment of chest tumors Effects of membrane trafficking on signaling by receptor tyrosine kinases.Analysis of receptor tyrosine kinase internalization using flow cytometry.Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer.Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation.

P2860

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P2860

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.

http://www.wikidata.org/entity/Q34097397

description

2005 nî lūn-bûn

@nan

2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@ast

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@en

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@nl

type

label

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@ast

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@en

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@nl

prefLabel

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@ast

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@en

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@nl

P1433

Q34097397-93B0CD4C-82CB-49C3-9859-4CB027111645

P1476

Q34097397-D1C8FF0C-60E4-4D2A-BDB7-976D1C677117

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P2860

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Q34097397-1D8B55D5-7942-4024-AB96-0A3D08B3F01C

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Q34097397-4CE72223-6098-4A99-95F3-14BE38C2EF61

P31

Q34097397-2813724D-083C-4B00-8E0D-09DC69FD63B7

P356

Q34097397-2339760E-BF63-425A-8F6C-6B802CD63953

P407

Q34097397-D2CC2D9B-F9DB-408B-8FDA-65A8021DE272

P433

Q34097397-5AC035FD-77D3-4DDB-8CF1-01FB79C8E44B

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Q34097397-14EFB3A2-7BE7-4F3F-9458-DE990C1134C7

P50

Q34097397-85B10FED-D986-47EE-A5D3-E469BEC24017

Q34097397-A884903D-11FC-479A-8132-1311B0F7F1BE

P577

Q34097397-568AFD94-622D-4963-B37F-0A803451C869

P698

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P921

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Q34097397-9EAC9241-BC5E-4725-946B-AF3D3C4FC611

P932

Q34097397-CB93D05E-2742-40E2-9FF5-C908C5E920C2

P356

MCB.25.21.9632-9645.2005

P1433

Molecular and Cellular Biology

P1476

Met/Hepatocyte growth factor r ...... uired for Hrs phosphorylation.

@en

P2093

Caroline Saucier

http://www.w3.org/2001/XMLSchema#string

Jasmine V Abella

http://www.w3.org/2001/XMLSchema#string

Monica A Naujokas

http://www.w3.org/2001/XMLSchema#string

Morag Park

http://www.w3.org/2001/XMLSchema#string

Tong Lin

http://www.w3.org/2001/XMLSchema#string

P2860

Syntaxin-16, a putative Golgi t-SNARE

Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.

Hrs recruits clathrin to early endosomes

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes

The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

Receptor downregulation and multivesicular-body sorting

Oncogenic kinase signalling

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

P304

9632-9645

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.25.21.9632-9645.2005

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

25

http://www.w3.org/2001/XMLSchema#string

P50

Pascal Peschard

P577

2005-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16227611

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

protein ubiquitination

P932

1265818

http://www.w3.org/2001/XMLSchema#string