LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy - Wikidata - awgldk - TriplyDB

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

http://www.wikidata.org/entity/Q24681561

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Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways Lrig2-deficient mice are protected against PDGFB-induced glioma LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis.Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor The LRIG family: enigmatic regulators of growth factor receptor signaling.Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2 Slitrks as emerging candidate genes involved in neuropsychiatric disorders Emerging role for ERM proteins in cell adhesion and migration.MicroRNA-19a promotes glioma cell growth by repressing LRIG1 Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer.LRIG and cancer prognosis.LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH.Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling.LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells.An antimetastatic role for decorin in breast cancer.Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer.The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies.Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.Genome-wide association study of colorectal cancer identifies six new susceptibility loci.Effects of membrane trafficking on signaling by receptor tyrosine kinases.Degradation of activated protein kinases by ubiquitination.Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer.New insights into the control of neurotrophic growth factor receptor signaling: implications for nervous system development and repair.LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor.Role of met axis in head and neck cancer.

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P2860

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

http://www.wikidata.org/entity/Q24681561

description

2007 nî lūn-bûn

@nan

2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@ast

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@en

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@nl

type

label

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@ast

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@en

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@nl

prefLabel

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@ast

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@en

LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@nl

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Molecular and Cellular Biology

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LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

@en

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Colleen Sweeney

http://www.w3.org/2001/XMLSchema#string

David L Shattuck

http://www.w3.org/2001/XMLSchema#string

Heidi Petersen

http://www.w3.org/2001/XMLSchema#string

Jamie K Miller

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Kermit L Carraway

http://www.w3.org/2001/XMLSchema#string

Melanie Funes

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Melanie Laederich

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P2860

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

Met, metastasis, motility and more

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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1934-46

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4179212

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10.1128/MCB.00757-06

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5

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27

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2007-03-01T00:00:00Z

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6621063

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17178829

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1820466

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