Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
about
The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifSignaling effect of amyloid-beta(42) on the processing of AbetaPPDifferential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's diseaseDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1The normal and pathologic roles of the Alzheimer's β-secretase, BACE1Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease miceBiological changes associated with healthy versus pathological aging: a symposium review.Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic CancerEvidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?Beta-secretase: structure, function, and evolution.Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREBMutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.Two novel DNA motifs are essential for BACE1 gene transcriptionNovel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Upregulation of human PINK1 gene expression by NFκB signalling5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.Differential regulation of BACE1 expression by oxidative and nitrosative signalsTranscriptional Regulation of TMP21 by NFAT.Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid depositionHypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionTolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies.Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brainCHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.The Alzheimer's disease beta-secretase enzyme, BACE1.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseLysophosphatidic acid induces increased BACE1 expression and Aβ formation.The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processingLifespan profiles of Alzheimer's disease-associated genes and products in monkeys and miceEffect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FADAlzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Mutant presenilin 1 increases the expression and activity of BACE1
P2860
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P2860
Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Transcriptional regulation of ...... rotein beta-secretase, by Sp1.
@en
type
label
Transcriptional regulation of ...... rotein beta-secretase, by Sp1.
@en
prefLabel
Transcriptional regulation of ...... rotein beta-secretase, by Sp1.
@en
P2093
P2860
P921
P1476
Transcriptional regulation of ...... rotein beta-secretase, by Sp1.
@en
P2093
Michelle A Christensen
Sjaak Philipsen
Weihui Zhou
P2860
P304
P356
10.1128/MCB.24.2.865-874.2004
P407
P577
2004-01-01T00:00:00Z