Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.
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RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infectionPhosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species.Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer.Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frameThe transcription factor ATF4 promotes skeletal myofiber atrophy during fasting.Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress.The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine.Endoplasmic reticulum stress in disease pathogenesisDual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesMolecular pathways: the PERKs and pitfalls of targeting the unfolded protein response in cancer.The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus.The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells.The integrated stress response.Eukaryotic translation initiation factors and cancer.Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo.Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition.Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.
P2860
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P2860
Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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2004年论文
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2004年论文
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name
Defects in translational regul ...... ormation of human fibroblasts.
@en
type
label
Defects in translational regul ...... ormation of human fibroblasts.
@en
prefLabel
Defects in translational regul ...... ormation of human fibroblasts.
@en
P2860
P1476
Defects in translational regul ...... ormation of human fibroblasts.
@en
P2093
Darren J Perkins
Glen N Barber
P2860
P304
P356
10.1128/MCB.24.5.2025-2040.2004
P407
P577
2004-03-01T00:00:00Z