Structural diversity and functional implications of the eukaryotic TDP gene family.
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Progranulin in frontotemporal lobar degeneration and neuroinflammationStructure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organismsSarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositisStructural insights into TDP-43 in nucleic-acid binding and domain interactionsRapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instabilityTDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicingRGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domainsPathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersTDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factorThe testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatidsβ-amyloid triggers ALS-associated TDP-43 pathology in AD modelsTARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathyIntrinsic disorder in proteins involved in amyotrophic lateral sclerosis.A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.White spot syndrome virus proteins and differentially expressed host proteins identified in shrimp epithelium by shotgun proteomics and cleavable isotope-coded affinity tagTDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosisTransgenic rat model of neurodegeneration caused by mutation in the TDP gene.TDP-43 is a developmentally regulated protein essential for early embryonic development.Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.A Drosophila model for TDP-43 proteinopathy.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismProfiling the genes affected by pathogenic TDP-43 in astrocytesUbiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chainsTransactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndromeThe role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.Neuronal function and dysfunction of Drosophila dTDPTAR DNA-binding protein 43 in neurodegenerative disease.Variations in the progranulin gene affect global gene expression in frontotemporal lobar degenerationElevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
P2860
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P2860
Structural diversity and functional implications of the eukaryotic TDP gene family.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Structural diversity and functional implications of the eukaryotic TDP gene family.
@en
type
label
Structural diversity and functional implications of the eukaryotic TDP gene family.
@en
prefLabel
Structural diversity and functional implications of the eukaryotic TDP gene family.
@en
P2093
P1433
P1476
Structural diversity and functional implications of the eukaryotic TDP gene family.
@en
P2093
C-K James Shen
Hurng-Yi Wang
I-Fan Wang
Jayaramakrishnan Bose
P304
P356
10.1016/S0888-7543(03)00214-3
P577
2004-01-01T00:00:00Z