Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability - Wikidata - awgldk - TriplyDB

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

http://www.wikidata.org/entity/Q24648173

about

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity Toward precision medicine in amyotrophic lateral sclerosis RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration Mutations in the Human AAA+ Chaperone p97 and Related Diseases TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Autophagosome dynamics in neurodegeneration at a glance The role of mTOR signaling in Alzheimer disease β-amyloid triggers ALS-associated TDP-43 pathology in AD models Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis.Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species Astrocytic TDP-43 pathology in Alexander disease Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells.Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model.Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.Regulation of autophagy by neuropathological protein TDP-43.Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43 Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence Structural and functional deviations in disease-associated p97 mutants.Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion.Disease animal models of TDP-43 proteinopathy and their pre-clinical applications.Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS.TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.Novel therapeutic approaches for inclusion body myositis.TDP-43 autoregulation: implications for disease.

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

http://www.wikidata.org/entity/Q24648173

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@ast

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@en

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@nl

type

label

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@ast

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@en

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@nl

prefLabel

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@ast

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@en

Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@nl

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JBC.M109.031278

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Journal of Biological Chemistry

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Rapamycin rescues TDP-43 mislo ...... mass neurofilament instability

@en

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Antonella Caccamo

http://www.w3.org/2001/XMLSchema#string

Fiona B Thornton

http://www.w3.org/2001/XMLSchema#string

Janice J Deng

http://www.w3.org/2001/XMLSchema#string

Salvatore Oddo

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Smita Majumder

http://www.w3.org/2001/XMLSchema#string

Yidong Bai

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P2860

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein

Higher order arrangement of the eukaryotic nuclear bodies.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

Autophagy: molecular machinery for self-eating

TOR, a central controller of cell growth.

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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