Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
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The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyMicrovesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activityC-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral strokeInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinA disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanismsADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and functionDiscovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activationADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formationADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domainFibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1The ADAMTS metalloproteinasesADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2.Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors.Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfateReactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implicationsADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.Proteases involved in cartilage matrix degradation in osteoarthritis.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageAntibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans?Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis.Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilageDevelopment of a solid-phase assay for analysis of matrix metalloproteinase activity.
P2860
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P2860
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
@en
type
label
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
@en
prefLabel
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
@en
P2093
P2860
P50
P356
P1476
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
@en
P2093
Christi Gendron
Hideaki Nagase
Masahide Kashiwagi
P2860
P304
10109-10119
P356
10.1074/JBC.M312123200
P407
P577
2003-12-08T00:00:00Z