G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsInteractions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesisG-CSF and GM-CSF in NeutropeniaOncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CMLNeutrophil cell surface receptors and their intracellular signal transduction pathways.Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.A screen for peptide agonists of the G-CSF receptorAkt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptorA novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infectionLyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Signal transduction pathways that contribute to myeloid differentiation.Multiple roles of Lyn kinase in myeloid cell signaling and function.JAK redux: a second look at the regulation and role of JAKs in the heart.G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation.Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.Systems approach to phagocyte production and activation: neutrophils and monocytes.Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.Severe congenital neutropenias.miR-155 is associated with the leukemogenic potential of the class IV granulocyte colony-stimulating factor receptor in CD34⁺ progenitor cells.Gab adapter proteins as therapeutic targets for hematologic disease.G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cellsG-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML
P2860
Q21245511-7B815E7B-8662-4EFF-89E6-E5802A10B19FQ24299293-B2D311EE-0E22-43C7-8E1E-3E3CB141C0D9Q26800954-535BB39B-FE52-4D0A-A054-C4EE658B6A56Q27852275-D94831E6-DC48-49B9-9E82-14040A4C1201Q30009577-88223B0A-0E85-4376-8065-4D7A99DB96EAQ33780538-93D1361C-1556-4788-9896-B1C53E1ACC5FQ33933699-1F060B0E-8FAE-4273-A4AE-4A2FB3CDDF35Q35071667-61A1BA7B-C32F-494C-8A7A-D80E9DB9F9E7Q35080710-D89058E9-D55F-4F7E-86A9-A41A3B567848Q35856940-C4F0D2BD-732A-4935-BEE5-6BC2B322B524Q36508969-85CA7614-ABBD-4E85-91E3-1D755C36FF7FQ36795284-388DE76A-74C2-4E70-A79C-82811FE463B1Q37416257-9D643EB4-18CC-4E6E-8D04-73632F9A8808Q37430884-36F489CF-A749-4F4F-883A-B7796D8586C5Q37459752-95C557A4-E120-4C20-9F0B-79D3FB724DEBQ37608488-164A814D-D0F3-4F59-B80A-AE39774F477BQ38284004-6C20E91E-2494-4167-B118-05B3596638B0Q39068979-B7784613-F653-4E3C-8798-253F9D35CEF2Q39359222-D011C274-F680-48A8-B2C7-5C35C02299D4Q39675707-71A9A7AC-5140-46A4-8A79-A2D4FEDC6D53Q39998279-88C45DD3-F8F2-413D-A36F-C02440E23CB5Q40352398-82B1CE93-E8EF-4123-B62E-ACBB02E3D852Q41766374-6142E612-E0F9-40F4-A42C-9E65DE28E35CQ42051165-EB606CA5-59F7-45A7-BB22-34BAE7072221Q42664472-DDF55B1A-8516-40DD-AAA8-1E2DC063628F
P2860
G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
G-CSF-induced tyrosine phospho ...... not proliferative, responses.
@en
type
label
G-CSF-induced tyrosine phospho ...... not proliferative, responses.
@en
prefLabel
G-CSF-induced tyrosine phospho ...... not proliferative, responses.
@en
P2093
P1433
P1476
G-CSF-induced tyrosine phospho ...... not proliferative, responses.
@en
P2093
Lisa J Robinson
Quan-Sheng Zhu
Seth J Corey
Vera Roginskaya
P304
P356
10.1182/BLOOD-2003-06-1861
P407
P577
2003-12-04T00:00:00Z