Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.
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Immature truncated O-glycophenotype of cancer directly induces oncogenic featuresA systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.Functional genomics for personalized cancer therapy.Next-generation sequencing-based panel testing for myeloid neoplasms.Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies.Genomics of chronic neutrophilic leukemia.Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.Enhanced MAPK signaling is essential for CSF3R-induced leukemia.CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AMLRecent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.Chronic neutrophilic leukemia: new science and new diagnostic criteria.Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation.
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Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Ligand independence of the T61 ...... creased receptor dimerization.
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Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor
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type
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Ligand independence of the T61 ...... creased receptor dimerization.
@en
Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor
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prefLabel
Ligand independence of the T61 ...... creased receptor dimerization.
@en
Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor
@nl
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Ligand independence of the T61 ...... creased receptor dimerization.
@en
P2093
Jason D MacManiman
Julia E Maxson
Melissa L Abel
Samuel B Luty
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P304
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10.1074/JBC.M113.508440
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P577
2014-01-08T00:00:00Z