A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity.
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Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esteraseOrganotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoidsDHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteinsCompound library development guided by protein structure similarity clustering and natural product structureCharting biologically relevant chemical space: a structural classification of natural products (SCONP)11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.Evidence for expression of 11β-hydroxysteroid dehydrogenase type3 (HSD11B3/HSD11B1L) in neonatal pig testis.Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus.Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UVAdamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Carbonyl reduction pathways in drug metabolism.Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis.Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee?Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase.13-Ethoxy-carbonyl-16-(1-methyl-ethyl)-17,19-dinoratis-15-ene-4,14-dicarboxylic acid monohydrate: a new derivative of maleopimaric acidMaleopimaric acid acetic acid solvate.Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism.Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue.Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?Differential effect of polyphenol-rich dark chocolate on biomarkers of glucose metabolism and cardiovascular risk factors in healthy, overweight and obese subjects: a randomized clinical trial.Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity
P2860
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P2860
A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
A rapid screening assay for in ...... 1beta-HSD1 reductase activity.
@en
type
label
A rapid screening assay for in ...... 1beta-HSD1 reductase activity.
@en
prefLabel
A rapid screening assay for in ...... 1beta-HSD1 reductase activity.
@en
P2093
P1476
A rapid screening assay for in ...... 1beta-HSD1 reductase activity.
@en
P2093
Alex Odermatt
Brigitte M Frey
Roberto A S Schweizer
P356
10.1016/J.MCE.2003.09.027
P577
2003-12-01T00:00:00Z