IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
about
Interleukin-2 receptor signaling: at the interface between tolerance and immunityMechanism of dichotomy between CD8+ responses elicited by apoptotic and necrotic cellsThe quantal theory of how the immune system discriminates between "self and non-self"Regulating the immune system via IL-15 transpresentationStimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ.CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.New insights into the regulation of T cells by gamma(c) family cytokinesCompeting feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments.In vivo cyclophosphamide and IL-2 treatment impedes self-antigen-induced effector CD4 cell tolerization: implications for adoptive immunotherapy.The Erk2 MAPK regulates CD8 T cell proliferation and survival.Shaping successful and unsuccessful CD8 T cell responses following infection.CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can directly bind CD4+ T cells and modulate their responseIntrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infectionGamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2.c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.IFN-λ exerts opposing effects on T cell responses depending on the chronicity of the virus infection.IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infectionT cell and APC dynamics in situ control the outcome of vaccinationCD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.Regulating functional cell fates in CD8 T cells.Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.Interleukin-2-dependent mechanisms of tolerance and immunity in vivoCD4 memory T cells divide poorly in response to antigen because of their cytokine profileCutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program.CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors.T cell exhaustion during persistent viral infections.Co-expression of tumor antigen and interleukin-2 from an adenoviral vector augments the efficiency of therapeutic tumor vaccinationT-cell activation and transplantation tolerance.Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation.Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses.Rapid down-regulation of γc on T cells in early SIV infection correlates with impairment of T-cell function.Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells.Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.
P2860
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P2860
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
@en
type
label
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
@en
prefLabel
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
@en
P1476
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
@en
P2093
Leo Lefrançois
Warren N D'Souza
P304
P356
10.4049/JIMMUNOL.171.11.5727
P407
P577
2003-12-01T00:00:00Z